iGame is regulated by Malta and powered by Netent casino games. Both Malta and Netent do not accept citizens from the United States of America.
I sent an email to the iGame support to get a clear explanation. Here is their answer :
Unfortunately we do not accept US players. If you are registered at US address then you can not unfortunately play from outside of US either.
As part of the US gambling law, iGame preferred to step back from the US Markets. However, some online casinos still continue to accept US citizens. Check our top 3 US Casinos.
Technically, you could play to iGame if you signed up from abroad. For instance if you are in vacation in Vietnam or in Mexico, you could play to iGame while you drink your Mai Tai. However, you should not use a US address and an american credit card (from Wells Fargo for instance).
This is the same problem as "signing-up from abroad". You could use a VPN to play to iGame, but you would need to have a real address outside of the US (with phone bill at your name for instance). If you have a sister abroad, for instance in the Brazil, it could work. Otherwise, in case you win a $9,000,000 jackpot, iGame could block your funds..
We know that Bovada is currently accepting US citizens. It is powered by Top Game software and offers a nice welcome bonus.